Clinical description an illness of gradual onset with one or more of the following: - malaise, fever, headache, sore throat, cough, nausea, vomiting, diarrhea, myalgia, chest pain, hearing loss, and - a history of contact with excreta of rodents or with a probable or confirmed case of lassa fever laboratory criteria for diagnosis. Background: the epidemiological, clinical and laboratory description, and treatment outcome of lassa fever (lf) in jos, nigeria methods: a retrospective study from january 2012 -february 2013 data analyzed included patients' demographics and clinical features main laboratory variable of interest was lf polymerase. Lassa fever 10 provincial reporting confirmed and probable cases of disease 20 type of surveillance case-by-case 30 case classification 31 confirmed case demonstration of virus antigen in an appropriate clinical specimen (eg blood, serum, tissue) by enzyme description of revisions december 2014. In particular, there is a dearth of data on the prevalence and clinical differentiation of lassa virus disease (lvd) in febrile children in endemic areas of nigeria, which has multiple lineages of the virus the aim of this study was to determine the prevalence and presentation of lvd in febrile children with and. Bichat guidelines for the clinical management of haemorrhagic fever viruses (filoviridae), lassa fever and new world arenaviruses less than 1% of patients develop haemorrhagic fever syndrome 2 to 4 days after the onset of the illness clinical features are the same as those observed in. We report a case of lassa fever in a us traveler who visited rural liberia, became ill while in country, sought medical care upon return to the united states, and subsequently had his illness laboratory confirmed the patient recovered with supportive therapy no secondary cases occurred.
A critical overview of lassa virus infection in the west african sub-region with consideration of the origin of the virus, its properties/strains, epidemiol- ogy and clinical presentation, treatment, prevention and control as well as the current theories of its patho- genesis and efforts in vaccine development studies reported in. Nigeria s u m m a r y objectives: despite the epidemic nature of lassa fever ( lf), details of outbreaks and response strategies have not been well documented in resource-poor settings we describe the course of a lf outbreak in ebonyi state, nigeria, during january to march 2012 methods: we analyzed clinical,. Receiving health care from a provider who is also treating lassa patients • sexual partner of a known or suspected case (virus can be present in semen for up to 3 months after clinical recovery) clinical assessment • non-specific clinical features: early diagnosis difficult • high index of suspicion • detailed clinical.
Guinea lassa fever is endemic throughout guinea, but most clinical cases have been reported from kindia, faranah and nzerekore regions lassa fever: map of guinea (jpeg, 146mb). Lassa fever is a viral haemorrhagic fever transmitted by rats it has been known since the 1950s, but the virus was not identified until 1969, when two missionary nurses died from it in the town of lassa in nigeria found predominantly in west africa, it has the potential to cause tens of thousands of deaths even after recovery. Lassa fever is a viral disease spread by the the multimammate rat it is widespread in many african countries, such as liberia and sierra leone, and can be fatal this mnt knowledge center article will discuss the disease in detail , including how to diagnose and treat it, as well as any steps to prevent it.
In this review we have shown that past biases in lf research have produced an incomplete picture of the disease's true incidence and distribution in west africa, with consequences for medical treatment and disease management we therefore close by emphasizing. Background this review summarises the history, aetiology, clinical presentation, management and prevention of lassa fever, with emphasis on the epidemiological findings from nigeria method relevant search of articles on “ lassa fever” published between 1969 and august 2012 was undertaken using pubmed, ajol.
. Lassa virus infection in nigeria: clinical perspective overview vincent idemyor, pharmd introduction lassa virus belongs to the family known as arenavirus and is classified as a segmented neg- ative-strand rna virus the family arenavirus is comprised of 23 virus species and is serologically and phylogenetically.
The mode of presentation of lassa fever can be non-specific and hence the difficulty in clinical diagnosis of some cases however the classical modes of presentation include high grade fever 38°c, sore throat, retrosternal pain, cough , odynophagia, conjunctivitis, petechial hemorrhages, abdominal pains, vomiting and.
Lassa virus (lasv) infection causes an acute, multisystemic viral hemorrhagic fever that annually infects an estimated 100 000 to 300 000 persons in west africa this pathogenesis study evaluated the temporal progression of disease in guinea pigs following aerosol and subcutaneous inoculation of the josiah strain of. Multi-system disease lassa fever is also associated with occasional epidemics, during which the case-fatality rate can reach 50% case definition the case definition below is the standard cdc case definition for viral hemorrhagic fevers ( vhf) clinical description an illness with acute onset with all of the following.
Case presentation: we report a case of a 59-year old female with fever who was initially thought to have acute pyelonephri- tis and sepsis syndrome with background malaria further changes in her clinical state and laboratory tests led to a suspicion of lassa fever however at the time her laboratory confirmatory test for. Name: lassa virus synonym or cross reference: lassa fever, lassa fever virus, viral haemorrhagic fever ( vhf ) characteristics: double- segmented, single-stranded rna virus, belonging to the genus arenavirus lassa fever: epidemiology, clinical features, and social consequences. The aim of this paper is to report the first two cases of lassa fever infection in togo case presentation the two first lassa fever cases occurred in two expatriate's health professionals working in togo for more than two years the symptoms appeared among two health professionals of a clinic located in oti.